Variables Arg/Arg Arg/Pro Pro/Pro Arg Allele frequency Pro Allele frequency Chi square p value
Gender              
Males 18(22.5) 48(60.0) 14(17.5) 0.52 0.48 0.17 0.92
Females 4(20.0) 13(65.0) 3(15.0) 0.53 0.47    
Age at diagnosis
<45 2(14.3) 10(71.4) 2(14.3) 0.50 0.50 0.8 0.67
>45 20(23.3) 51(59.3) 15(17.4) 0.53 0.47    
TNM Stage              
Early Stage ( I and II ) 15(42.9) 20(57.1) 0(0.0) 0.71 0.29 19.9 <0.0001
Advanced Stage ( III and IV ) 7(10.8) 41(63.0) 17(26.2) 0.42 0.58    
Distant Metastasis
Positive 3(10.7) 8(28.6) 17(60.7) 0.25 0.75 52.7 <0.0001
Negative 19(26.4) 53(73.6) 0(0.0) 0.63 0.37    
Histological type
ADC 8(16.0) 31(62.0) 11(22.0) 0.47 0.53 3.1 0.21
SCC 14(28.0) 30(60.0) 6(12.0) 0.58 0.42    
Grade (ADC)
Well 5(45.5) 6(54.5) 0(0.0) 0.73 0.27 20.7 0.0004
Moderately  3(25.0) 9(75.0) 0(0.0) 0.63 0.38    
Poorly Differentiated 0(0.0) 16(59.3) 11(40.7) 0.30 0.70    
Grade (SCC)
Well 9(32.1) 15(53.6) 4(14.3) 0.59 0.41 1.8 0.77
Moderately  4(28.6) 9(64.3) 1(7.1) 0.61 0.39    
Poorly Differentiated 1(12.5) 6(75.5) 1(12.5) 0.50 0.50    
Smoking status
Non Smokers 8(26.7 ) 18(60.0) 4(13.3) 0.57 0.43 0.77 0.68
Smoker 14(20.0) 43(61.4) 13(18.6) 0.51 0.49    
Current Smokers 4(14.3) 17(60.7) 7(25.0) 0.45 0.55 1.8 0.41
Ex Smokers 10(23.8) 26(61.9) 6(14.3) 0.55 0.45    
Smoking Levels (Pack Year)
Mild (≤10) 0(0.0) 6(85.7) 1(14.3) 0.43 0.57 4.5 0.33
Moderate (≤ 40) 8(24.2) 21(63.6) 4(12.2) 0.56 0.44    
Heavy (> 40) 6(20.0) 16(53.3) 8(26.7) 0.47 0.43    
Family history of any cancer
Significant 3(16.7) 11(61.1) 4(22.2) 0.47 0.53 0.64 0.73
Non Significant 19(23.2) 50(60.9) 13(15.9) 0.54 0.46    
Table 4: Frequency of P53 exon 4 (72 codon) in NSCLC patients.