Variables P53 mutations OR( 95%CI) p value
  Positive (%) Negative (%)    
Gender        
Females 15(75.0) 5(25.0) 1  
Males 63(78.8) 17(21.2) 1.24(0.39-3.88) 0.71
Age at diagnosis(Years)        
>45 65(75.6) 21(24.4) 1  
≤45 13(92.9) 1(7.1) 4.2(0.52-34.0) 0.14
TNM Stage        
Early Stage( I and II ) 26(74.3) 9(25.7) 1  
Advanced Stage ( III and IV ) 52(80.0) 13(20.0) 1.4(0.52-3.66) 0.51
Distant Metastasis        
Negative 52(72.2) 20(27.8) 1  
Positive 26(92.8) 2(7.2) 5.0(1.08-23.0) 0.02
Smoking Status        
Non Smokers 27(90.0) 3(10.0) 1  
Smokers 51(72.9) 19(27.1) 0.30(0.08-1.10) 0.05
Smoking Level        
Mild (≤10) 6(85.7) 1(14.3) 1  
Moderate (≤40) 23(69.7) 10(30.3) 0.38(0.04-4.4) 0.38
Heavy (>40) 22(77.3) 8(26.7) 0.45(0.04-4.4) 0.49
Histological Type        
SCC 35(70.0) 15(30.0) 1  
ADC 43(86.0) 7(14.0) 2.6(0.97-7.2) 0.04
Grade(ADC)        
Well 8(72.7) 3(27.3) 1  
Moderately  11(91.7) 1(8.3) 4.1(0.36-47.3) 0.23
Poorly Differentiated 24(88.9) 3(11.1) 3.0(0.50-18.0) 0.21
Grade(SCC)        
Well 19(67.9) 9(32.1) 1  
Moderately  9(64.3) 5(35.7) 0.9(0.22-3.3) 0.81
Poorly Differentiated 7(87.5) 1(12.5) 3.3(0.35-31.2) 0.27
P53 Codon 72 Genotype
Arg/Arg 17(77.3) 5(22.7) 1  
Arg/Pro 45(73.8) 16(26.2) 0.82(0.26-2.61) 0.75
Pro/Pro 16(94.1) 1(5.9) 4.7(0.5-44.8) 0.14
  P53 Mutations (%)    
Histological Type Arg/Arg Arg/Pro or Pro/Pro  
ADC 7/8(87.5) 36/42(85.7) 0.9(0.08-8.3) 0.8
SCC 11/14(78.6) 24/36(66.7) 0.5(0.13-2.33) 0.4
Table 5: Association of clinical and pathological characteristics with p53 mutations in Non small cell lung cancer patients.