| Variables |
P53 mutations |
OR( 95%CI) |
p value |
| |
Positive (%) |
Negative (%) |
|
|
| Gender |
|
|
|
|
| Females |
15(75.0) |
5(25.0) |
1 |
|
| Males |
63(78.8) |
17(21.2) |
1.24(0.39-3.88) |
0.71 |
| Age at diagnosis(Years) |
|
|
|
|
| >45 |
65(75.6) |
21(24.4) |
1 |
|
| ≤45 |
13(92.9) |
1(7.1) |
4.2(0.52-34.0) |
0.14 |
| TNM Stage |
|
|
|
|
| Early Stage( I and II ) |
26(74.3) |
9(25.7) |
1 |
|
| Advanced Stage
( III and IV ) |
52(80.0) |
13(20.0) |
1.4(0.52-3.66) |
0.51 |
| Distant Metastasis |
|
|
|
|
| Negative |
52(72.2) |
20(27.8) |
1 |
|
| Positive |
26(92.8) |
2(7.2) |
5.0(1.08-23.0) |
0.02 |
| Smoking Status |
|
|
|
|
| Non Smokers |
27(90.0) |
3(10.0) |
1 |
|
| Smokers |
51(72.9) |
19(27.1) |
0.30(0.08-1.10) |
0.05 |
| Smoking Level |
|
|
|
|
| Mild (≤10) |
6(85.7) |
1(14.3) |
1 |
|
| Moderate (≤40) |
23(69.7) |
10(30.3) |
0.38(0.04-4.4) |
0.38 |
| Heavy (>40) |
22(77.3) |
8(26.7) |
0.45(0.04-4.4) |
0.49 |
| Histological Type |
|
|
|
|
| SCC |
35(70.0) |
15(30.0) |
1 |
|
| ADC |
43(86.0) |
7(14.0) |
2.6(0.97-7.2) |
0.04 |
| Grade(ADC) |
|
|
|
|
| Well |
8(72.7) |
3(27.3) |
1 |
|
| Moderately |
11(91.7) |
1(8.3) |
4.1(0.36-47.3) |
0.23 |
| Poorly Differentiated |
24(88.9) |
3(11.1) |
3.0(0.50-18.0) |
0.21 |
| Grade(SCC) |
|
|
|
|
| Well |
19(67.9) |
9(32.1) |
1 |
|
| Moderately |
9(64.3) |
5(35.7) |
0.9(0.22-3.3) |
0.81 |
| Poorly Differentiated |
7(87.5) |
1(12.5) |
3.3(0.35-31.2) |
0.27 |
| P53 Codon 72 Genotype |
| Arg/Arg |
17(77.3) |
5(22.7) |
1 |
|
| Arg/Pro |
45(73.8) |
16(26.2) |
0.82(0.26-2.61) |
0.75 |
| Pro/Pro |
16(94.1) |
1(5.9) |
4.7(0.5-44.8) |
0.14 |
| |
P53 Mutations (%) |
|
|
| Histological Type |
Arg/Arg |
Arg/Pro or Pro/Pro |
|
| ADC |
7/8(87.5) |
36/42(85.7) |
0.9(0.08-8.3) |
0.8 |
| SCC |
11/14(78.6) |
24/36(66.7) |
0.5(0.13-2.33) |
0.4 |
|
