MMP/TIMP Expression level Cancer subtype Cell type Correlation with prognosis Reference
MMP2 High - - Poor outcome [60]
Positive T1-2 tumor - Shorter survival [61]
High Lymph node-negative breast cancer - Shorter relapse-free survival [63]
High - - Shorter survival [64]
MMP9 High Lymph node-negative breast cancer - Shorter relapse-free survival [63]
High - Cancer cells Longer relapse-free survival [65]
Positive Estrogen receptor positive Stroma Shorter relapse-free survival and breast cancer-related survival
Low Invasive ductal carcinoma - Shorter relapse-free survival [34]
Positive Invasive ductal carcinoma Cancer cells Shorter relapse-free survival
Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival
High Basal like - Shorter relapse-free survival [34]
Positive Basal like Stroma (Fibroblast and MIC Shorter relapse-free survival
Positive Luminal A Stroma (Fibroblast and MIC Shorter relapse-free survival
MMP7 Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival [34]
MMP11 High - - Poor outcome [60]
High Invasive ductal carcinoma - Shorter relapse-free survival [34]
Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival
High Basal like - Shorter relapse-free survival [37]
Positive Basal like Stroma (Fibroblast and MIC) Shorter relapse-free survival
Positive Luminal A MIC Shorter relapse-free survival
High Invasive breast carcinomas Cancer cells Worse disease outcome [71]
Positive Invasive breast carcinomas Fibroblasts Adverse overall survival
MMP13 Positive Basal like MIC Shorter relapse-free survival [99]
Positive Luminal A Stroma (Fibroblast and MIC) Shorter relapse-free survival
MMP14 Positive Invasive ductal carcinoma MIC Shorter relapse-free survival [34]
Positive Luminal A MIC Shorter relapse-free survival 100
High - - Lymph node metastasis and/or lymph vessel invasion [67]
TIMP1 High Invasive ductal carcinoma - Shorter relapse-free survival [34]
Positive Invasive ductal carcinoma MIC Shorter relapse-free survival
  TIMP2 High Invasive ductal or lobular carcinomas or both - Shorter relapse-free survival and shorter survival [73]
High - - Shorter relapse-free survival [72]
High     Shorter relapse-free survival [71]
High - - Shorter relapse-free survival and shorter overall survival [70]
High - - Shorter relapse-free survival and shorter overall survival [69]
High Invasive ductal carcinoma - Shorter relapse-free survival [34]
Positive Invasive ductal carcinoma Cancer cells Shorter relapse-free survival
Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival
Positive Basal like Stroma (Fibroblast and MIC) Shorter relapse-free survival [100]
Positive Luminal A Stroma (Fibroblast and MIC) Shorter relapse-free survival
High Invasive ductal or lobular carcinomas or both - Shorter relapse-free survival [73]
High   Stroma Shorter relapse-free survival [75]
High - - Shorter relapse-free survival and shorter overall survival [74]
Table 2: Expression of MMPs and TIMPs and its relationship with clinical outcome of patients with breast cancer.