D-type 0.9 ≤ DI<1.2     A-type 1.2 ≤ DI<1.8 T-type 1.8 ≤ DI<2.2 SSI ≤ 5 14.6 ± 6.4 n=29 24.7 ± 13.6 n=3 20.6 ± 16.6 n=16 5<SSI ≤ 8.8 19.5 ± 14.4 n=75 26.2 ± 9.5 n=13 18.4 ± 11.1 n=32 7<SSI ≤ 11 20.6 ± 17.8 n=24 20.2 ± 9.5 n=59 17.9 ± 9.7 n=24 11<SSI ≤ 15 16.4 ± 7.8 n=26 17.6 ± 9.0 n=24 22.3 ± 13.1 n=33 13<SSI ≤ 20 15.5 ± 7.5 n=40 15.5 ± 8.1 n=25 21.5 ± 9.2 n=24 20<SSI ≤ 70 23.3 ± 10.7 n=15 24.3 ± 10.7 n=15 20.7 ± 8.7 n=29

Table 3: Relationship between tumor size and increasing SSI according to tumor type. The three ploidy entities were investigated according to tumor size related to five SSI intervals. The values in bold are highlighting two close tumor size values for each ploidy entities found in the size interval 10 to 20 mm (Figure1a). For D-, and A-type tumors it appears in the SSI-interval 11<SSI ≤ 20 relative units corresponding to the genomic reorganization found (Figure 3c-d and Figure 4c-d). For T-type tumors if was found at a lower level of genomic instability i.e. lower SSI values (5<SSI ≤ 11)(see Table 1b).