Bladder hyperplasia grade (bh-grade) Effect on bladder Cell layers 0 Normal 2-3 1 Slight hyperplasia 4 2 Slight/moderate hyperplasia 5-8 3 Moderate hyperplasia 9-10 4 Moderate/severe hyperplasia 10-12 5 Severe hyperplasia >12

Table 1: Classification of bladder hyperplasia in mice after hormone treatment. Bladder hyperplasia grade (bh-grade) was established on bladder tissue that was extended with fixative (10% formalin) at necropsy.