Control group n= 207 n (%) Cpk n= 33 n (%) Cpa n= 90 n (%)   ptotal p OR 95%CI
rs3136176
Genotype
[AA] 116 (56.0) 19 (57.6) 47 (52.2)   ns1 ns2 ns3 referent
[AT] 81 (39.2) 12 (36.4) 32 (35.6) Cpkvs.Cpa Control vs.Cpk Control vs.Cpa 0.86 0.80 1.00 0.93 0.90 0.98 0.40 – 2.17 0.42 – 1.97 0.57 – 1.66
[TT] 10 (4.8) 3 (6.1) 11 (12.2) Cpkvs.Cpa Cpkvs. Control Cpavs. Control 0.82* 0.64* 0.03 1.48 1.83 2.71 0.37 – 5.91 0.46 – 7.27 1.08 – 6.82
Allele
[A] 313 (75.6) 50 (75.8) 126 (70.0)                Cpkvs.Cpa Control vs.Cpk Control vs.Cpa   0.38 1.00 0.17 0.75 1.02 0.76 0.39 – 1.43 0.56 – 1.87 0.52 – 1.13
[T] 101 (24.4) 16 (24.2) 54 (30.0) Cpkvs.Cpa Cpkvs. Control Cpavs. Control   0.38 1.00 0.17 1.34 0.98 1.31 0.70 – 2.56 0.53 – 1.79 0.89 – 1.94
Dominant model
[AA] + [AT] vs. [TT] 197 (95.2) 31 (93.9) 79 (87.8) Cpkvs.Cpa Control vs.Cpk Control vs.Cpa   0.83 0.59 0.02 0.70 0.52 0.36 0.18 – 2.66 0.14 – 2.01 0.15 – 0.89
10 (4.8) 3 (6.1) 11 (12.2) Cpkvs.Cpa Control vs.Cpk Control vs.Cpa   0.83 0.59 0.02 1.44 1.91 2.74 0.38 – 5.51 0.50 – 7.32 1.12 – 6.72
Recessive model
[TT] + [AT] vs. [AA] 91 (44.0) 15 (42.4) 43 (47.8) Cpkvs.Cpa Cpkvs. Control Cpavs. Control   0.72 0.87 0.60 1.16 0.99 1.14 0.52 – 2.45 0.48 – 2.06 0.70 – 1.88
116 (56.0) 19 (57.6) 47 (52.2) Cpkvs.Cpa Cpkvs. Control Cpavs. Control   0.72 0.87 0.60 0.86 1.01 0.87 0.39 – 1.91 0.49 – 2.09 0.53 – 1.44
rs1799798
Genotype
[GG] 162 (78.3) 22 (66.7) 68 (75.6)   ns1 ns2 ns3 referent
[GA] 42 (20.3) 9 (27.3) 20 (22.2) Cpkvs.Cpa Cpkvs. Control Cpavs. Control 0.48 0.29 0.68 0.72 1.58 1.13 0.29 – 1.81 0.68 – 3.68 0.62 – 2.07
[AA] 3 (1.4) 2 (6.1) 2 (2.2) Cpkvs.Cpa Cpkvs. Control Cpavs. Control 0.57* 0.24* 1.00* 0.32 4.91 1.59 0.04 – 2.43 0.78 – 31.03 0.26 – 9.72
Allele
[G] 366 (88.4) 53 (80.3) 156 (86.7) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.22 0.07 0.55 1.59 0.53 0.85 0.76 – 3.35 0.27 – 1.05 0.50 – 1.44
[A] 48 (11.6) 13 (19.7) 24 (13.3) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.22 0.07 0.55 0.63 1.87 1.17 0.30 – 1.32 0.95 – 3.68 0.69 – 1.98
Dominant model
[GG] + [GA] vs. [AA] 204 (98.6) 31 (93.9) 88 (97.8) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.62* 0.29* 0.63* 2.84 0.23 0.65 0.38 – 21.02 0.04 – 1.42 0.11 – 3.94
3 (1.4) 2 (6.1) 2 (2.2) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.62* 0.29* 0.63* 0.35 4.39 1.55 0.05 – 2.61 0.71 – 27.31 0.25 – 9.41
Recessive model
[AA] + [GA] vs. [GG] 45 (21.7) 11 (33.3) 22 (24.4) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.32 0.14 0.61 0.65 1.80 0.86 0.27 – 1.54 0.81 – 3.99 0.48 – 1.54
162 (78.3) 22 (66.7) 68 (75.6) Cpkvs.Cpa Cpk vs. control Cpavs. Control   0.32 0.14 0.61 1.55 0.56 1.16 0.65 – 3.69 0.25 – 1.23 0.65 – 2.09
^– p-value after Bonferroni correction * – p-value after Yate’s correction; #– global p-value for genotype; rs3136176 1 – Cpk vs. Cpa: χ2= 1.000745, df= 2, p= 0.606335 2 – Cpk vs. controls: χ2= 0.154262, df= 2, p= 0.925770 3 – Cpa vs. controls: χ2= 5.223751, df= 2, p= 0.073497 rs1799798 4 – Cpk vs. Cpa: χ2= 1.615913, df= 2, p= 0.445826 5 – Cpk vs. controls: χ2= 4.057297, df= 2, p= 0.131621 6 – Cpa vs. controls: χ2= 0.394092, df= 2, p= 0.821159
Table 5: ERCC4rs3136176 and ERCC4rs1799798 alleles and genotypes frequencies in cervical squamous cell carcinoma (CSCC): carcinoma planoepitheliale keratodes (Cpk), and carcinoma planoepitheliale aceratodes (Cpa) and healthy women.