CR (n= 77) n (%) PD (n= 33) n (%) ptotal# p OR 95%CI
rs3136176
Genotype
[AA]
[AT]
[TT]
46 (59.7)
22 (28.6)
9 (11.7)
13 (39.4)
16 (48.5)
4 (12.1)
ns1 referent
0.035
0.76
2.51
0.64
1.06 – 6.27
0.17 – 2.40
Allele
[A]
[T]
114 (74.0)
40 (26.0)
42 (63.6)
24 (36.4)
  0.12 0.61
1.63
0.33 – 1.14
0.88 – 3.02
Dominant model
[AA] + [AT]
vs.
[TT]
68 (88.3) 9 (11.7) 29 (87.9) 4 (12.1)   0.80* 0.96 1.00 0.27 – 3.33 0.30 – 3.66
Recessive model
[TT] + [AT]
vs.
[AA]
31 (40.3) 46 (59.7) 20 (60.6) 13 (39.4)   0.05 2.28 0.48 0.99 – 5.26 0.19 – 1.00
rs1799798
Genotype
[GG]
[GA]
[AA]
56 (72.7)
17 (22.1)
4 (5.2)
26 (78.8)
7 (21.2)
0 (0.0)
ns2 referent
0.81
0.43
0.89
0.33 – 2.40
Allele
[G]
[A]
129 (83.8)
25 (16.2)
59 (89.4)
7 (10.6)
  0.28 1.63
0.61
0.67 – 3.99
0.25 – 1.50
Dominant model
[GG] + [GA]
vs.
[AA]
73 (94.8) 4 (5.2) 33 (100.0) 0 (0.0)   0.61* – – – –
Recessive model
[AA] + [GA]
vs.
[GG]
21 (27.3) 56 (72.7) 7 (21.2) 26 (78.8)   0.50 0.72 1.39 0.27 – 1.90 0.53 – 3.69
^p-value afterBonferroni correction
* – p-value after Yate’s correction
# – global p-value for genotype
1 - χ2= 4.438183, df= 2, p= 0.108815
2 - χ2= 1.836043, df= 2, p= 0.399375
Table 7: ERCC4 rs3136176 and ERCC4 rs1799798 genotype and allele frequencies in squamous cell cervical cancer (CSCC) patients with disease remission (CR) and disease progression (PD).