CR (n= 77) n (%) PD (n= 33) n (%) ptotal# p OR 95%CI
rs3136176
Genotype
[AA] [AT] [TT] 46 (59.7) 22 (28.6) 9 (11.7) 13 (39.4) 16 (48.5) 4 (12.1) ns1 referent
0.035 0.76 2.51 0.64 1.06 – 6.27 0.17 – 2.40
Allele
[A] [T] 114 (74.0) 40 (26.0) 42 (63.6) 24 (36.4)   0.12 0.61 1.63 0.33 – 1.14 0.88 – 3.02
Dominant model
[AA] + [AT] vs. [TT] 68 (88.3) 9 (11.7) 29 (87.9) 4 (12.1)   0.80* 0.96 1.00 0.27 – 3.33 0.30 – 3.66
Recessive model
[TT] + [AT] vs. [AA] 31 (40.3) 46 (59.7) 20 (60.6) 13 (39.4)   0.05 2.28 0.48 0.99 – 5.26 0.19 – 1.00
rs1799798
Genotype
[GG] [GA] [AA] 56 (72.7) 17 (22.1) 4 (5.2) 26 (78.8) 7 (21.2) 0 (0.0) ns2 referent
0.81 0.43 0.89 – 0.33 – 2.40 –
Allele
[G] [A] 129 (83.8) 25 (16.2) 59 (89.4) 7 (10.6)   0.28 1.63 0.61 0.67 – 3.99 0.25 – 1.50
Dominant model
[GG] + [GA] vs. [AA] 73 (94.8) 4 (5.2) 33 (100.0) 0 (0.0)   0.61* – – – –
Recessive model
[AA] + [GA] vs. [GG] 21 (27.3) 56 (72.7) 7 (21.2) 26 (78.8)   0.50 0.72 1.39 0.27 – 1.90 0.53 – 3.69
^p-value afterBonferroni correction * – p-value after Yate’s correction # – global p-value for genotype 1 - χ2= 4.438183, df= 2, p= 0.108815 2 - χ2= 1.836043, df= 2, p= 0.399375
Table 7: ERCC4 rs3136176 and ERCC4 rs1799798 genotype and allele frequencies in squamous cell cervical cancer (CSCC) patients with disease remission (CR) and disease progression (PD).