Cancer Type EGFR expression HER-2 expression Approved Targeted Therapy
Breast Cancer Yes Yes lapatinib, trastuzumab, pertuzumab, T-DM1
Colorectal Cancer Yes Yes cetuximab, panitumumab
Gastric Cancer (GEJ) No Yes Trastuzumab
HNSCC Yes No Cetuximab
NSCLC Yes No afatinib, erlotinib, gefitinib
Pancreatic Cancer Yes Yes Erlotinib
Table 1: Overview of indications for approved targeted therapies against EGFR and HER-2.