| Ab (Mabthera) |
B-cell dysfunction, infusion-related cytokine release, hypersensitivity, cardiac arrythmias [18] |
| Immunotoxin (CAT-3888,CAT-8015) |
Drug-related toxicities in 25-60% of the 28 patients included (indecreasing frequency), grade 1-2 hypoalbuminemia, edema, fever, ALT and AST elevations, headaches, and nausea [19,20] |
| Antibody-drug |
Hematosuppression neutropenia, neuropathy [18]
conjugate (Brentuximab) |
| Ab (HER2/neu |
Cardiomyopathy, infusion-related cytokine release [18] |
| Toxin (orellanine) |
Severe injury to tubule cells in the kidney [21] |
| Radiotherapy |
Immune defect, infectious complications [22] |
| Platinol |
Renal insufficiency, hearing loss, neuropathy [18] |
| 6-OH DOPA |
Severe neurotoxicity [11] |
| Ab (CTLA4) |
Autoimmune reaction [23] |
| Ab (PD-1) |
Autoimmune reaction [23] |
| T-cell (transplantation) |
Graft vs. host [24] |
|
