Figure 2: Microscopic appearance of the pancreatic biopsy specimen. (A); Scarce amount of pancreatic tissue adjacent to atypical cell proliferation in a solid nodular pattern (H&E;x40). (B); Pleomorphic atypical tumour cells with occasional bizarre nuclei and eosinophilic cytoplasm are seen. Distinct melanin pigment in the center is remarkable. (H&E;x400). (C); Strong HMB-45 immunoreactivity of the tumour cells is observed (H&E;x200). (D); Strong S-100 immunoreactivity of the tumour cells is seen (H&E;x200).