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Figure 2: IPA analysis based hnRNPD networks in oral cancer. Network analysis obtained using Ingenuity Pathway Analysis (IPA)demonstrating interactions (direct / indirect) of hnRNPD with proteins involved in cellular signaling pathways including mTOR and eNOS;Double strand DNA repair mechanism (XRCC5, XRCC6); Chromatin remodeling (SMARCC1, SMARCC2, SMARCB1, SMARCD1,SMARCD2, SMARCE1 and histone family of proteins including H1, H2A, H2B & H4); Telomere maintenance (hnRNP A2/B1, XRCC5,XRCC6, hnRNP A1); RISC (short-interfering-RNA-mediated gene silencing) (EIF2C1, EIF2C2, EIF2C3), RNA splicing, stability, translationand decay (ribosomal proteins 28S, 40S and 60S; ATP dependent RNA helicases, mRNA cap guanine-N7 methyltransferase, RNMT, RAE1,PTBP1, FIP1L1, DHX15, RSL1D1, RBMS1, RBM12B). |