Variables Cases (N=172) Controls (N=154) Pa
Age, mean(SD) 62.2 (10.0) 61.7 (11.0) 0.660
Sex, N (%)
  Male 163 (94.8) 137 (89.0)  
  Female 9(5.2) 17(11.0) 0.053
Smoking status, N (%)
  Never 41 (23.8) 74 (48.0)  
  Former 92 (53.5) 60 (39.0)  
  Current 39 (22.7) 20 (13.0) <0.001
  Never 41 (23.8) 74 (48.0)  
  Ever 131 (76.2) 80 (52.0) <0.001
Pack-years, mean(SD) 70.2 (68.1) 49.4 (63.2) 0.030
Range of pack-years, N (%)
  None 41 (23.8) 74 (49.0)  
<45 57 (33.1) 48 (31.8)  
  ≥45 74(43.1) 29 (19.2) <0.001
BMIb, N(%)
<25 62 (39.7) 46 (30.3)  
  25-30 60 (38.5) 62 (40.8)  
  ≥30 34 (21.8) 44 (28.9) 0.163
Family history of all cancers, N (%)
  No 23 (13.4) 29 (18.8)  
  Yes 149 (86.6) 125 (81.2) 0.179
Family history of esophageal cancer, N (%)
  No 164 (95.3) 145 (94.2)  
  Yes 8(4.7) 9 (5.8) 0.629
GERD, N (%)
  No 61 (35.5) 128 (83.1)  
  Yes 111 (64.5) 26 (16.9) <0.001
BE, N (%)
  No 103 (60.2) 151 (98.1)  
  Yes 68 (39.8) 3(1.9) <0.001
Table 1: Distribution of host characteristics by case-control status . Abbreviations: SD- Standard Deviation; BMI-Body Mass Index; GERD- Gastroesophageal Reflux Disease; BE-Barrett’s Esophagus; TM- Tail Moment; BPDE, benzo[a]pyrene diol epoxide. aP values were derived from χ2 test for categorical data (i.e. sex, ethnicity, smoking status, family history of cancer, family history of esophagus cancer, GERD status, BE status), from the Student t-test for continuous variables (i.e. age ) and from the Wilcoxon rank-sum test for packyears. bBMI of three years prior to cancer diagnosis for EAC patients and interview for control participants.