DNA damage variables Cases Controls Adjusted OR(95% CI)a Pb Baseline TM By 75th percentile value, N (%)         Lowc 117 (68.0) 116 (75.3) 1.00 (ref.)   Highd 55 (32.0) 38 (24.7) 1.66 (0.91-3.05) 0.100 Net BPDE-induced TM By 75th percentile value, N (%)         Lowc 90 (62.9) 90 (75.0) 1.00 (ref.)   Highd 53 (37.1) 30 (25.0) 2.15 (1.13-4.10) 0.020 Net γ radiation-induced TM By 75th percentile value, N (%)         Lowc 109 (65.3) 110 (75.3) 1.00 (ref.)   Highc 58 (43.1) 36 (24.7) 2.27 (1.24-4.16) 0.008 Both net BPDE-induced and net γ radiation-induced TM Low 66 (46.8) 66 (55.9) 1.00 (ref.)   Intermediatee 41 (29.1) 40 (33.9) 1.60 (0.80-3.20) 0.182 High 34 (24.1) 12 (10.2) 4.02 (1.64-9.86) 0.002 P for trend  0.002

Table 3: Risk Estimates of EAC for baseline, net BPDE-induced and net γ radiation induced DNA Damage. c Adjusted by sex, age, smoking status, GERD and BE status, family history of all cancer. bP values were derived from the Wilcoxon rank-sum test for baseline TM, net BPDE-induced TM, and net γ radiation-induced TM. c“Low” referred to subjects with TM<75% cut-off of the controls. d“High” referred to subjects with TM ≥75% cut-off of the controls. e Participants were classified as having induced DNA damage value either ≥75% for net γ radiation-induce TM and <75% for net BPDE-induced TM or ≥ 75% for net BPDE-induced TM and <75% for net γ radiation-induced TM.