Figure 4: LANA reduces the TAP63a induced MMP loss. Cells tranfected with TAp63α alone and with both TAp63α and LANA were flow cytometrically assessed for reduction in MMP loss by DiOC6 fluorescence. The figure shows the representative results of three independent experiments. After the DiOC6 treatment, the percentage of viable cells is highest in doxorubicin-treated TAp63α- LANA co-transfected cells compared to the other two groups of doxorubicin-treated cells. It suggests that the TAp63α-mediated loss of MMP may be reduced by the presence of LANA, indicating another mechanism to prevent apoptosis in cells. p< 0.05 was considered to reveal a significant difference.