Family MMPs Key characteristics
Collagenases MMP-1, -8, and -13 These can cleave collagen and are able to process other ECM molecules
Gelatinases MMP-2 and -9 Play an important role in the remodeling of collagenous ECM, also targeting other ECM and non-ECM molecules
Stormelysins MMP-3, and -10 Process many ECM components as well as some growth factors, cytokines and adhesion molecules, except for the native collagen
Stormelysin-like MMPs MMP-11, and -12 MMP-11- induced in adipose tissue by cancer cells, and is responsible for tumor progression through the degradation of collage VI.
Matrylisins MMP-7, and -26 Play important roles in degradation and processing of ECM and non-ECM proteins
Transmembrane MMPs also known as MT1-, MT2-, MT3- and MT5-MMP respectively MMP-14, -15, 16, and -24 Located on the cell surface and control the local environment of normal and tumor cells. Main activators of proMMP-2 and are involved in blood vessel formation. Also upregulated in tumors and in some cases associated with poor prognosis of several types of cancer.
Glycosyl-phospatidyl-inositol (GPI)- type MMPs also known as MT4- and MT-6-MMP MMP-17, and -25
  MM-19-like MMPs MMP-19 and -28 Produced by several carcinomas although their role is not yet well defined. MMP28 is believed to play a role in several diseases of the central nervous system (CNS) including multiple sclerosis.
Other MMPs MMP-18, -20, and -23 MMP23 - produced by various normal tissues but their precise roles have not yet been elucidated
Disintegrin/Metalloproteinase ADAMs (a disintegrin and metalloproteinase) and the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) An interaction between MMPs and ADAMTS was reported with MT4-MMP contributing to activation of ADAMTS-4
Table 1: The classification of MMPs.