Genetic Model Cancer Heterogeneity Association analysisb Publication Bias Q-testa I2-test OR 95% CI Pc Pd Begge Eggerf RQ vs. RR Cervical     0.84 0.48 – 1.48 0.55 0.50       Prostate     1.06 0.74 – 1.53 0.74         Overall 0.46 0.0% 0.99 0.73 – 1.35 0.97   τ=-0.33, p=0.33 p=0.59 QQ vs. RR Cervical     0.32 0.13 – 0.74 <0.01 <0.01       Prostate     2.26 1.15 – 4.44 0.02         Overall <0.01 82% 1.06 0.63 – 1.80 0.82   τ=-0, p=0.75 p=0.90 QQ+RQvsRR Cervical     0.68 0.40 – 1.18 0.17 0.09       Prostate     1.19 0.85 – 1.68 0.31         Overall 0.18 39% 1.02 0.76 – 1.36 0.91   τ=-0, p=0.75 p=0.98 QQ vs. RQ+RR Cervical     0.35 0.16 – 0.77 <0.01 <0.01       Prostate     2.18 1.12 – 4.23 0.02         Overall <0.01 82% 1.03 0.62 – 1.71 0.92   τ=-0, p=0.75 p=0.47 QvsR Cervical     0.64 0.43 – 0.94 0.02 <0.04       Prostate     1.28 0.97 – 1.68 0.08         Overall 0.01 74% 1.02 0.81 – 1.27 0.89   τ=0.33, p=0.33 p=0.59

ap-value was calculated by Cochran ψ2-based Q test using RevMan v5.3 bSignificant associations are bold cTest of overall effect dComparison between pooled ORs for prostate and cervical cancer, p-value was determined by the ψ2-test eBegg-Mazumdar test was used to calculate publication bias. Results are given as Kendall's tau and p-value (any less than 0.1 was consider significant for publication bias) fEgger’s test was used to calculate publication bias. Results are given as a p-value (any less than 0.1 was consider significant for publication bias).

Table 2: Meta-analysis results for RNASEL R462Q mutation among Latin Americans Cancer subjects.