Primary
Figure 3: I - Primary cancerogenic hyper cycle. 11 - Genome instability and mutation 12 - "RNA world": long non-coding RNA, dsRNA, siRNA, miRNA; II - Intracellular cyclic reactions. 1 - Resisting cell death, 2 - Sustaining proliferative signaling, 3 - Evading growth suppressors, 5 - Enabling replicative immortality, 7 - Deregulating cellular energetics, 9 - Development of medicinal resistance; III - Tissue cyclic reactions, 6 - I nducing angiogenesis, 8 - Evoiding immune destruction, 10 - Tumor promoting inflammation; IV- Cyclic reactions at the level of an organism, 4 - Activating invasion and metastasis.