| Number |
Author |
Year |
Model |
Tissue |
Doses/area |
Exposure |
Comet parameter |
Mean |
Observed effects |
| 1 |
Flora et al. [31] |
2004 |
Rat |
Blood |
10mgKg-1 |
5days/wk/12wk |
tail length |
no data |
heavy DNA damage |
| 2 |
Yanezet al. [33] |
2003 |
Human |
Blood |
Villa de la Paz |
±2years |
tail length, tail moment |
67.6µm, 6.8 |
significant damage |
| |
|
|
|
|
Matehuala |
|
|
41.7µm, 3.2 |
in Villa de la Paz |
| 3 |
Basuet al. [24] |
2005 |
Human |
Blood |
West Bengal |
±5years |
%DNA tail |
59.74±10.54µm |
|
| |
|
|
|
|
|
|
Tail length |
58.68±10.23µm |
DNA damage |
| |
|
|
|
|
|
|
Tail moment |
42.31±11.58 |
|
| |
|
|
|
|
|
|
Comet length |
83.33±15.51µm |
|
| 4 |
Paluset al. [30] |
2005 |
Human |
Blood |
Poland |
±18years |
Tail moment |
13.2x10-3 |
significant damage |
| 5 |
Paluset al.[38] |
2006 |
Mice |
Blood |
50µg/L |
3,6,12 months |
Tail moment |
0.14±0.11,0.02±0.02,0.14±0.07 |
significant damage |
| |
|
|
|
|
200µg/L |
3,6,12 months |
|
0.16±0.12,0.03±0.01,0.02±0.01 |
at 50µg/L |
| |
|
|
|
|
500µg/L |
3,6,12 months |
|
0.12±0.06,0.03±0.01,0.03±0.03 |
|
| 6 |
Vuyyuriet al.[34] |
2006 |
Human |
Blood |
India |
minimum 3 year |
Tail length |
14.95±0.21µm |
signficant damage |
| 7 |
Banerjee et al. [35] |
2008 |
Human |
Blood |
Murshidabad |
±10year |
Olive tail moment |
2.76±1.39 |
significant damage |
| |
|
|
|
|
|
|
%DNA tail |
14.05±4.71 |
|
| |
|
|
|
|
|
|
Tail length |
11.85±5.51 |
|
| 8 |
endez-Gomez et al.[36] |
2008 |
Human |
Blood |
Mexico(3 school around arsenic location) |
minimum 6 month |
Tail length |
|
|
| |
|
|
|
|
Distant |
|
|
29.2 |
significant damage |
| |
|
|
|
|
Intermediate |
|
|
25.3 |
in nearest compared |
| |
|
|
|
|
Nearest |
|
|
28.6 |
to intermediate |
| 9 |
Akramet al.[29] |
2009 |
Rat |
Ovary |
50,100,200ppm |
28 days |
Tail moment |
0.09±0.01,0.45±0.05,0.50±0.05 |
significant damage |
| |
|
|
|
|
|
|
Tail length |
17.98±1.39, 20.61±1.45,22.12±1.49 |
maximum at high dose |
| |
|
|
|
|
|
|
%DNA tail |
0.43±0.02,1.73±0.08,2.12±0.11 |
|
| |
|
|
|
|
|
|
Olive tail moment |
0.08±0.01,0.40±0.04,0.50±0.04 |
|
| 10 |
Ahmad et al. [39] |
2011 |
Fish |
Liver |
3ppm |
48,96,192hrs |
%DNA in tail |
>10, >20, >20 |
significant, with |
| |
|
|
|
|
28ppm |
|
|
>30, >40, >30 |
maximum damage |
| |
|
|
|
|
56ppm |
|
|
>40, >50, >40 |
at 96hr |
| 11 |
Ahmad et al. [39] |
2011 |
Fish |
Blood |
3ppm |
48,96,192hrs |
%DNA tail |
>10, >10, >10 |
significant, with |
| |
|
|
|
|
28ppm |
|
|
>20, >30, >20 |
maximum damage |
| |
|
|
|
|
56ppm |
|
|
>30, >40, >30 |
at 96hr |
| 12 |
Flora et al.[32] |
2012 |
Mice |
Blood |
5mg l-1 |
28 weeks |
Tail length |
>150µm |
significant damage |
| 13 |
Jasso-Pineda [37] |
2012 |
Human |
Blood |
San Luis Potosi state(3 communities) |
|
|
|
|
| |
|
|
|
|
community 1 |
±6year |
Tail moment |
5.2±0.6 |
significant damage |
| |
|
|
|
|
community 2 |
±6year |
|
3.5±0.4 |
|
| |
|
|
|
|
community 3 |
±7year |
|
2.5±0.4 |
|
|
