Figure 1: Scheme for CD44-targeting therapy using sulfasalazine (modified from Reference 12); System xc(−) is a cystine/glutamate exchange transporter composed of a light-chain subunit (xCT) and a heavy-chain subunit (CD98hc); CD44v maintains a high level of intracellular GSH by stabilizing the expression of xCT at the plasma membrane, and thereby associates with resistance to cancer therapy; Sulfasalazine is an agent which inhibits this cystine/ glutamate transporter system.