MOC Mechanism Genes Up/Down Regulation Chemoprotection/ chemoresistance
1a Drug Uptake SLC22A1 Down Increased
SLC22A5 Up Decreased
SLC28A1 Down Increased
1b Drug Export ATP7A Up Increased
ABCB1 Up Increased
ABCC2 Up Increased
ABCG2 Up Increased
ABCC6 Down Decreased
MVP Down Decreased
2 Drug Metabolism CES1 Down Decreased
CYP1A2 Down Decreased
GSTA1 Down Decreased
UPP1 Up Increased
3 Drug Targets DHFR Down Increased
  TOP1 Up Increased
4 DNA Repair None    
5a Apoptosis BCL2L1 Up Increased
BIRC3 Up Increased
DIABLO Down Decreased
5b Survival BCL2L1 Up Increased
BIRC5 Up* Increased
MAPK1 Up Decreased
MYC Up* Increased
NAIP Up Increased
NFKB1 Up Increased
PIK3CG Up Increased
RPL6 Up* Increased
XIAP Up Increased
Table 1: Changes in the expression of genes involved in chemoresistance/chemoprotection in HB.