Figure 1: ETS factors are classified into distinct subclasses. The different subclasses of ETS factors are classified according to the presence or absence of the ETS domain (DNA binding domain) and the PNT domain (pointed domain). The generic structure depicted aligns each class according to the ETS domain (shaded gray) and includes the pointed domain (PNT, shaded black). The PNT domain can range from 65-80 amino acids in length and is important for proteinprotein interactions. TEL1 and TEL2 make up the TEL subclass and each has a PNT domain. These two proteins can homo and hetero dimerize. This dimerization likely affects the activity of each protein.