Figure 3: IPA analysis of the array data in our laboratory demonstrates the significant changes of RAN signaling pathway in prostatospheres. Genes highlighted in red suggest the significant increase of expression in prostatospheres compared to adherent cells. In PCSC1 (A) and PCSC3 (B) primary patient cell lines, prostatospheres have an increase of gene expression in RAN signaling pathway. Each symbol stands for a molecule with different function as follows: diamond: enzyme; ellipse: transcription regulator; trapezium: transporter; circle: others. Regular arrows mean “acts on” and arrows with outlined triangles stand for “translocates to”.