Figure 1: Proteoglycan decorin in desmoplastic reaction associated with Kaposi´s sarcoma. A.Immunohistochemical staining of Kaposi´s sarcoma tissue sample with an antibody to the endothelial cell marker CD31 [38]. B. In Situ Hybridization (ISH) of consecutive tissue section for decorin. Decorin ISH was performed on Kaposi´s sarcoma tissue sample with human decorin antisense and sense single-stranded RNA riboprobes [38]. Positive reaction in ISH can be seen in purple. Note that decorin is heavily expressed in the ECM surrounding the sarcoma tissue. Asterisks in A and B indicate the tumour mass. Arrows in B point to the border between the sarcoma tissue and its surrounding ECM. Scale bar in A and B, 100 μm.