Molecule Core protein size (kDa) GAG type (number of GAGs)
SLRPs Decorin 40 CS/DS (1)
Biglycan 40 CS/DS (1-2)
Asporin 43 none
Fibromodulin 58 KS (4)
Lumican 38 KS (2-3)
Modular PGs Versican (isoforms V0- V4) 370, 262, 180, 72, 115 (V0-V4) CS/DS (0-23)
  Aggrecan 210-250 CS (100) KS (30)
Brevican 50,80,145 CS (0-5)
Perlecan 400-467 HS (3-10)/(CS, DS, hybrid
HS/CS, CS/DS chains or
GAG-free glycoprotein)
HA* Very low, low, medium
and high HA species
Molecular weight (kDa)
50, 300, 800, 2000-3000
Repeating glucuronic acid and
N-acetylglucosamine
disaccharides
*HA is the only GAG synthesized in a free form lacking a protein core.
Table 1: Extracellular matrix PGs and HA in tumour microenvironment.