Agent Mechanism Cell type Reference Ionizing radiation DNA-Damage Oxidative stress Primary, Tumor cells [18, 30] H2O2 Oxidative stress Primary [31] Na Butirate Epigenetic silencing Primary, Tumor cells [32] Cisplatin, doxorubicin, aphidicolin, etoposide, citarabine, BrDU DNA-damage Oxidative stress Primary, Tumor cells [18] [30,23] Retinoids Differentiating agent Primary, Tumor cells [33,34] Taxol, vincristine Microtubule targeting Primary, Tumor cells [18, 30]

Table 2: Agents inducing senescence.