Figure 1: Hepatocarcinogenicity of MeIQx in rats. Male F344 rats were treated with MeIQx at wide range of doses for 2,4,16 and 32 weeks for the examination of GST-P+ foci development (A), MeIQx adducts (B) and 8-OHdG formation in DNA (C). (D) Incidence of lacI gene mutations and development of GST-P+ foci was detected in the liver of Big Blue rats treated with MeIQx for 16 weeks. (E) Reaction curves for the carcinogenicity markers dependent on the dose of MeIQx exposure. This is an illustration for MeIQx effects in log-log scale.