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Table 3: Mean mtDNA copy number by CDKN2A mutation status. P-values were obtained by comparing CDKN2A mutation carriers and non-carriers by CMM status using linear regression analysis of natural log-transformed data adjusting for familial correlation in the variance using a generalized estimating equation approach (P) with further adjustment for age at blood draw and sex (P*). Using box-cox transformed (λ=-0.75) data did not alter the results significantly. # Geometric means (or exponentiation of log-transformed mtDNA copy number). |