CMM Cases mtDNACoN# CDKN2A-  Non-Carrier (n=77) CDKN2A+ Carrier (n=59) Model P N     (%) N     (%) OR  (95% CI)   Q1 (<83) 22     (28.6) 11  (18.6) Ref   Q2 (83-106) 20     (26.0) 17  (28.2) 1.69 (0.66-4.4) 0.273 Q3 (107-164) 26     (33.8) 13  (22.0) 0.98 (0.36-2.65) 0.961 Q4  (>164) 9     (11.7) 18 (30.5) 5.04 (1.5-17) 0.009 Ptrend   1.48 (1.05-2.1) 0.024

Table 4: Association between mtDNA copy number in blood and risk of being a CDKN2A+ carrier case. Odds ratios and P-values were computed using an unconditional logistic regression model adjusted for age at blood draw, sex, and familial correlation using a generalized estimating equation approach. Abbreviations: mtDNACoN =mitochondrial DNA copy number; OR = odds ratio; CI = confidence interval; SD = standard deviation; Q1 = quartile 1; Q2 = quartile 2; Q3 = quartile 3 and Q4 = quartile 4; and # = exponentiation of log-transformed mtDNA copy number.