CMM Cases
mtDNACoN#  CDKN2A-Non-Carrier (n=77) CDKN2A+ Carrier(n=59) Model P
N (%) N (%) OR  (95% CI)  
Q1 (<83) 22 (28.6) 11 (18.6) Ref  
Q2 (83-106) 20 (26.0) 17 (28.2) 1.69 (0.66-4.4) 0.273
Q3 (107-164) 26 (33.8) 13 (22.0) 0.98 (0.36-2.65) 0.961
Q4 (>164) 9  (11.7) 18 (30.5) 5.04 (1.5-17) 0.009
Ptrend   1.48 (1.05-2.1) 0.024
Table 4: Association between mtDNA copy number in blood and risk of being a CDKN2A+ carrier case. Odds ratios and P-values were computed using an unconditional logistic regression model adjusted for age at blood draw, sex, and familial correlation using a generalized estimating equation approach. Abbreviations: mtDNACoN =mitochondrial DNA copy number; OR = odds ratio; CI = confidence interval; SD = standard deviation; Q1 = quartile 1; Q2 = quartile 2; Q3 = quartile 3 and Q4 = quartile 4; and # = exponentiation of logtransformed mtDNA copy number.