Gene Name Gene Alias UniProt Protein Name Protein Alias cDNA Change Mutation type Protein Change BCOR KIAA1575 Q6W2J9 BCL-6 corepressor BCoR c.5486G>T Nonsense p.E1732 BCORL1   Q5H9F3 BCoR-L1 BCoR-like protein 1 c.3989G>A Missense p.R1292Q CREBBP CBP Q92793 CREB-binding protein --- c.4541G>A Missense p.R1446H c.4765G>T Missense p.D1521Y c.1711C>T Nonsense p.Q503 c.3053C>T Missense p.T950M c.964G>C Missense p.A254P EHMT1 UHMTASE1, GLP, KIAA1876, KMT1D Q9H9B1 EHMT1 Eu-HMTase1, GLP, GLP1, H3-K9-HMTase 5. c.1157G>A Missense p.D374N c.168G>C Missense p.G44A EHMT2 BAT8, C6orf30, G9A, KMT1C, NG36 Q96KQ7 EHMT2 Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, H3-K9-HMTase 3 c.1155C>T Missense p.S384L EP300 P300 Q09472 p300 HAT E1A-associated protein p300 c.4549G>T Missense p.C1385F c.4590G>A Missense p.D1399N c.4154G>T Missense p.C1385F H2BFWT --- Q7Z2G1 Histone H2B type W-T H2B histone family member W testis-specific c.451C>T Missense p.R143C H3F3A H3.3A, H3F3, H3.3B P84243 H3.3 --- c.122C>T Missense p.R3C H3F3C --- Q6NXT2 H3.3C H3.5 c.439A>G Missense p.K122E c.172A>G Missense p.T33A HDAC3 --- O15379 HD3 RPD3-2, SMAP45 c.968G>T Missense p.R301L HDAC4 KIAA0288 P56524 HD4 --- c.3452G>T Missense p.G887V HDAC9 HDAC7, HDAC7B, HDRP, KIAA0744, MITR Q9UKV0 HD9 HD7, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR c.2643C>A Missense p.H868N HIST1H1B H1F5 P16401 H1.5 H1a, H1b, H1s-3 c.727G>C Missense p.K225N HIST1H1E H1F4 P10412 H1.4 H1b, H1s-4 c.146G>A Missense p.G29D HIST1H2AJ H2AFE Q99878 H2A type 1-J H2A/e c.89G>A Missense p.R30Q c.56C>T Missense p.S19F HIST1H2BF HIST1H2BC, HIST1H2BE, HIST1H2BG, HIST1H2BI P62807 H2B type 1-C/E/F/G/I H2B/a, H2B/g, H2B/h, H2B/k, H2B/l c.229G>A c.152C>G Missense Missense p.E77K p.P51A HIST1H2BH H2BFJ Q93079 H2B type 1-H H2B/j c.9T>G Missense p.D3E c.67C>A Missense p.Q23K HIST1H3A HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J P68431 H3.1 H3/a, H3/b, H3/c, H3/d, H3/f, H3/h, H3/I, H3/j, H3/k, H3/l c.125A>G Missense p.Y42C c.90G>A Missense p.R27Q c.120A>T Missense p.K37M c.103A>T Missense p.T33S HIST1H4B HIST1H4A, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 P62805 H4 --- c.202C>T Missense p.R68W c.77A>T Missense p.N26I c.162G>C Missense p.E54D c.11G>A Missense p.R4K c.262G>T Missense p.V88F c.118C>G Missense p.R40G c.39A>T Missense p.K13I HIST2H2AB --- Q8IUE6 H2A type 2-B --- c.133G>A Missense p.G45R HIST2H2BE H2BFQ Q16778 H2B type 2-E H2B-GL105, H2B/q c.247G>A Missense p.D69N KDM3A JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA Q9Y4C1 Lysine-specific demethyla, se 3A Jumonji domain-containing protein 1A c.3698C>G Missense p.S1124C c.4178C>A Nonsense p.S1284 KDM4A JHDM3A, JMJD2, JMJD2A, KIAA0677 O75164 Lysine-specific demethylase 4A Jumonji domain-containing protein 2A c.174C>T Missense p.S3F c.503G>A Missense p.E113K c.2150G>T Missense p.A662S KDM4B JHDM3B, JMJD2B, KIAA0876 O94953 Lysine-specific demethylase 4B Jumonji domain-containing protein 2B c.1418T>C Missense p.S398P KDM5A JARID1A, RBBP2, RBP2 P29375 Lysine-specific demethylase 5A Jumonji/ARID domain-containing protein 1A, RBBP-2 c.5287G>C Missense p.G1642R c.2708G>A Missense p.R782Q KDM5B JARID1B, PLU1, RBBP2H1 Q9UGL1 Lysine-specific demethylase 5B CT31, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1, RBP2-H1 c.1741A>T Missense p.Y542F c.2368G>A Missense p.C751Y KDM5C DXS1272E, JARID1C, SMCX, XE169 P41229 Lysine-specific demethylase 5C Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, SmcX, protein Xe169 c.1539G>C Missense p.D336H MYST1 KAT8, MOF Q9H7Z6 MYST-1 Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein1, hMOF c.829C>G Missense p.L271V MYST2 KAT7, HBO1, HBOa O95251 MYST-2 KAT7, Histone acetyltransferase binding to ORC1 Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 c.179C>T Missense p.S18F c.1016_1017delTT Frame_Shift_Del p.L297fs MYST3 MOZ, KAT6A, RUNXBP2, ZNF220 Q92794 MYST-3 KAT6A, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 c.3999G>T Missense p.W1152L NAT10 ALP, KIAA1709 Q9H0A0 N-acetyltransferase 10   c.1598G>A Missense p.A452T PHF21A BHC80, KIAA1696 Q96BD5 PHD finger protein 21A BHC80a BRAF35-HDAC complex protein BHC80 c.2553C>G Missense p.I643M c.2491C>T Missense p.R623C RCOR1 KIAA0071, RCOR Q9UKL0 REST corepressor 1 CoREST c.e3_splice_site Splice_Site_SNP   RCOR2 --- Q8IZ40 REST corepressor 2 --- c.731A>T Nonsense p.K115 RCOR3 KIAA1343 Q9P2K3 REST corepressor 3 --- c.559A>T Missense p.M122L TNP2 --- Q05952 TP-2 --- c.206C>A Missense p.S55R

Data represents HNSCC mutations reported by Stransky N. et al, and Agrawal et al supplemented by UniProt database (http://www.uniprot.org/). Only missense and nonsense mutations along with frame shift deletions and splice site SNP of histones and histones associated modifiers were included. Synonymous mutations were excluded.

Table 3: Histones and histones modifiers found mutated in HNSCC (NGS).