Figure 1: The CAM emerges as a standard model of carcinogenesis. “Chorioallantoic membrane” and “cancer” were entered as search terms on PubMed (, and the results were sorted by date of addition to PubMed database. The number of articles published per year was quantified, and Student’s t-test was used to analyze the difference in the number of publications using the CAM method between decades. Between the 1970s and 1980s and beyond there is a statistically significant increase in the number of articles, and the largest increase occurred between the 1990s and 2000s. Given this trend, it is likely that an increasing number of cancer researchers will employ the CAM model.