| microRNAs |
Target genes |
Chromosome |
Function |
Cell lines |
Citations |
| miR-34a
miR-192
miR-215 |
Cdkn1A/p21 |
miR-192/194; 11
miR-215/194; 1 |
Increase apoptosis
Cell cycle arrest
Suppress carcinogenesis |
|
[24] |
| miR-34s |
CDK6, E2F3
Cyclin E2, Bcl-2 |
miRNA-34a; 1p36
miRNA-34b/34c;
11q23 |
Cell cycle arrest
Apoptosis |
U2OS
SaOS2 |
[25] |
| miR-31 |
E2F2, p14
p16 |
9p21.3 |
Cell cycle, Promote p53 activity, Induce apoptosis |
U2OS |
[30] |
| 14q32 miRs
(miR-382, 369-
3p, 544, 134) |
cMyc
miR-17-92 |
14q32 |
Pro-apoptotic effect |
SaOS2 |
[33] |
| miR-20a |
Fas |
C13orf25 |
Induce metastasis
Reduce Fas-mediated apoptosis |
LM7
SaOS2 |
[31] |
| miR-17-92 |
LRRC17,
RGMB, LIMA1,
CCNE1,
VAMK2N1 |
C13orf25 |
Oncogenic & tumor suppressor properties, Differentiation, Apoptosis, Cell cycle regulation |
HOS58,
U2OS, SaOS2,
SJSA1, MG63 |
[32] |
| 14q32 miRs |
HDAC |
14q32 |
Elevate histone deacetylase activity |
SaOS2 |
[34] |
| miR-15
miR16-1 |
CCND1 |
|
Apoptosis, Cell cycle arrest |
SOSP-9607 |
[35] |
| miR-29a |
Bcl-2, Mcl-1,
E2F1, E2F3 |
|
Down-regulated in Osteosarcoma, Induce apoptosis (p53-independent) Down-regulate Bcl-2, Mcl-1, Increase tumor suppressor genes, E2F1 and E2F3 |
U2OS
SaOS2 |
[36] |
| miR-93 |
E2F1 |
|
Reduce cell viability, Promote apoptosis, Suppress tumorigenesis |
MG63, 143B |
[37] |
| miR-143 |
Bcl-2 |
|
|
MG63, U2OS |
[38] |
| miR-221 |
PTEN |
|
Increase cell survival and cisplatinresistance, Decrease apoptosis |
SOSP-9607,
MG63 |
[39] |
| miR-223 |
Heat shock
protein
90B1(HSP90B1) |
|
Suppress HSP90B1 and cell growth, Cell cycle arrest and apoptosis. Decrease PI3K/Akt/mTOR/ Bcl-2. Increase Bid |
MG63 |
[40] |
|
