Figure 3: Immunohistochemistry of BPH and PCa biopsies using the antigen retrieval method to demonstrate the expression of Bax. This can be mapped against the distribution of p53 which also shows strong positivity in PCa biopsies. The expression of Bax was also strongly immunopositive in BPH biopsies showing evidence of senescence. Comparing this against the p53 expression levels in Figure 2 above, it shows that Bax play an important role in cell proliferation rather than cell cycle dysregulation. S 29 which showed high p53 expression is also characterized by the highest Bax expression. Over expression of Bax and P53 might be an evidence of apoptosis in this case rather than tumorgenesis (magnification X400).