| Cancer location |
Genes in the network |
| Hypopharyngeal |
ALOX12B, CCL4, CD48, IGFBP3, IRF4, LAMB3, LDHA, PCBP1, S100A2, SFN,SPP1,TMEM109
|
| Oral cavity |
ARHGAP1,ASS1, BCL2, BHMT, BMP4, CEP57, COL1A2, CPEB3, CR2,CSF1, CXCR5, DNAJC16, FAS, GNLY, GPR64, GZMB, HNRNPK, IER3, IFNB1, MMP9, NFKB2, NOD2, PERP, PLA2G4A, PLAU, PSMA2, SEMA4C, SERPINE1, SERPINF1, STAT4, TGFBI, TNC |
| Both locations |
ALDOA, IL1B,IL6, IL8, MMP1, PTX3, SELE, TP63, TPM1, |
The target genes of transcription factors and miRNAs were predicted using
the matrix decomposition-based method, based on microarray datasets of
hypopharyngeal [124] and oral [125] metastatic vs. non- metastatic tumor tissues.
Genes are presented as uniquely identified in hypopharyngeal cancer or oral
cancer, or as appearing in both locations. Genes in bold are consistent with those
genes differentially expressed and predicted to be under the regulation of NF-κB
and TP53 in HNSCC cell lines with different TP53 mutation status [18,19]. |
