Figure 2: Schematic structures of MAGI, AKT, and PTEN protein. The predicted consensual domain structures for each protein are depicted. The functionally important sites including the sites of protein phosphorylation are also shown. Note that the sizes of protein are modified for clarity. PH domain=pleckstrin homology domain; C2 domain=a protein structural domain involved in targeting proteins to cell membranes; PDZ=a common structural domain in signaling proteins (PSD95, Dlg, ZO-1, etc); WW=WW domain (also known as WWP domain) with two highly conserved tryptophans.