Nanoparticles  Size (nm) Photosensitizer   In vitro   In vivo   Reference Marix MRI contrast agents Shell Targeing molecule Type of imaging Nature Cellular type In vivo model Gold - PEG anti-HER2 Antibody   4 C11Pc MCF-10A SKBR-3 MDA-MB-231   [36] PAA - PEG F3 Peptide   - Methylene blue MDA-MB-435   [23] PAA - PEG F3 Peptide   60 Methylene blue 9L MDA-MB-435 MCF-7 F98   [24] Chitosane glycol - -   fluorescence 280 PpIX SCC-7 HT-29 mouse [60] Iron oxyde Iron oxyde -   MRI 20 Ce6 MGC803 MGC803 mouse [61] fluorescence Cristaux (NaYF4, Yb, Er)   PEG Folic acid   30 Ce6+ doxorubicine KB HeLa   [40] Iron oxyde Iron oxyde -   MRI 11 TSPP   mouse [62] Chitosan Iron oxyde     MRI 20 PHPP SW480 SW480 mouse [63] Silica Iron oxyde     MRI 20-30 PHPP SW480   [64] Silica   -   fluorescence 105 Methylene blue HeLa HeLa mouse [65] PAA Iron oxyde PEG F3 MRI 40 Photofrin® MDA-MB-435 9L rat [25] Silica Iron oxyde -   MRI 55 Ir(III) complex HeLa   [38] Silica Iron oxyde -   MRI 30 Methylene blue     [37] PAA Iron oxyde PEG RGD   30-60 Photofrin® MDA-MB-435 MCF-7 9L rat [17,18]

Table 1: Recent studies using multifunctional nanoparticles.