Compound |
Cell type |
ERK1/2 |
p38 |
JNK |
EGFR |
Ca2+ |
ROS |
Reference |
TGZ |
Rat liver epithelial cells GN4 |
0 |
+ |
|
0 |
+ |
|
[43,45] |
Hepatic cells HepG2 |
0 |
+ |
+ |
|
|
|
[66] |
Porcine aorta endothelial stable cell lines expressing EGFR (PAE-EGFR) |
+ |
|
|
+ |
|
|
[65] |
Colorectal cancer cells HCT15 and HT29 |
+ |
|
|
|
|
|
[58] |
Colorectal cancer cells HCT-116 |
+ |
|
|
|
|
|
[59] |
Breast cancer cells MCF-7 |
+ |
+ |
+ |
|
|
|
[61] |
Breast cancer cells MCF-7 |
+ |
|
|
+ |
|
|
[38] |
Breast cancer cells MCF-7 |
+ |
|
|
|
+ |
|
[47] |
Prostate cancer cells LNCaP |
+ |
+ |
|
|
|
|
[31] |
Normal human urothelial cells (NHU) |
+ |
+ |
|
|
+ |
|
[46] |
Lung cancer A549 and 3T3 cells |
|
|
|
|
+ |
|
[41,42] |
Mouse embryonic stem cells |
|
|
|
|
+ |
|
[40] |
Δ
2-TGZ |
Lung cancer A549 and 3T3 cells |
|
|
|
|
+ |
|
[41,42] |
Rat liver epithelial cells GN4 |
0 |
+ |
|
0 |
|
|
[43,45] |
Breast cancer cells MCF-7 |
+ |
|
|
0 |
+ |
|
[47] |
CGZ |
Mouse preadipocyte cell line 1B8
Cultured primary astrocytes |
+ |
+ |
+ |
|
|
+ |
[60] |
Myoblast C2C12 |
+ |
|
|
|
|
+ |
[52] |
Rat liver epithelial cells GN4 |
+ |
+ |
|
+ |
+ |
+ |
[43,45,64] |
PAE-EGFR cells |
+ |
|
|
|
|
|
[65] |
Breast cancer cells MCF-7 |
+ |
|
|
|
|
|
[47] |
Fibrosarcoma cells HT1080 |
+ |
|
|
|
|
+ |
[51] |
Astroglioma cells C6 |
|
|
|
|
|
+ |
[53,54] |
Glioma cells A172 |
+ |
+ |
|
|
|
|
[56] |
Prostate cancer cells LNCaP |
+ |
+ |
|
|
|
|
[31] |
Normal human urothelial cells (NHU) |
+ |
+ |
|
|
+ |
|
[46] |
Lung cancer cells A549 and 3T3 cells |
|
|
|
|
+ |
|
[42] |
D2-CGZ |
Rat liver epithelial cells GN4 |
+ |
+ |
|
+ |
|
|
[43,45] |
RGZ |
Renal cancer cells (CaKi cells) |
|
|
|
|
|
+ |
[50] |
Astroglioma cells C6 |
|
|
|
|
|
+ |
[53,54] |
Rat liver epithelial cells GN4 |
|
0 |
|
+ |
|
|
[45] |
Lung cancer cells A549 |
|
|
|
|
0 |
|
[42] |
Lung cancer cells H1838 (NSCLC) |
+ |
+ |
|
|
|
|
[63] |
Cultured primary astrocytes |
0 |
0 |
|
|
|
|
[60] |
Hepatic cells HepG2 |
|
0 |
0 |
|
|
|
[66] |
PAE-EGFR cells |
0 |
|
|
|
|
|
[65] |
Colorectal cancer cells HT-29 |
+ |
+ |
|
|
|
+ |
[49] |
Breast cancer cells MCF-7 |
0 |
|
|
|
|
|
[47] |
Normal human urothelial cells (NHU) |
+ |
+ |
|
|
+ |
|
[46] |
PGZ |
Astroglioma cells C6 |
|
|
|
|
|
+ |
[54] |
Rat liver epithelial cells GN4 |
|
0 |
|
|
|
|
[45] |
PAE-EGFR cells |
0 |
|
|
|
|
|
[65] |
TZD18 |
Breast cancer cells (MDA-MB231, MCF-7) |
+ |
+ |
+ |
|
|
|
[26] |
STG28 |
Prostate cancer cells LNCaP |
+ |
+ |
|
|
|
|
[31,62] |
OSU-CG12 |
Prostate cancer cells LNCaP |
+ |
+ |
|
|
|
|
[31] |
Breast cancer cells MCF-7 |
+ |
+ |
|
|
|
|
[31] |