Figure 1: Nestin structure and transcriptional regulation of the nestin gene. The nestin gene, localized to the long arm of chromosome 1, consists of 4 exons and 3 introns: Exon 1, bases 1-916; Intron 1, bases 917-2058; exon 2, bases 2058-2182; Intron 2, bases 2183-3870; Exon 3, bases 3871-3944; intron 3, bases 3945-4192; exon 4, bases 4193-8635. Octamer-binding transcription factor 4 (Oct4); retinoic acid receptor (RAR); retinoid X receptor (RXR); and Thyroid Hormone Receptor (TR).