Figure 3: (A) In vivo imaging of the vascular metastasis model of pancreatic cancer in the NOG mouse showed bioluminescence localized in the lung regions (red arrowheads) after 6 hours. The intensity was reduced at 1 week, but then increased again at the lung regions and also appeared at the liver region at 3 weeks (yellow arrowheads). (B) Ex vivo imaging of excised internal organs showed marked light emission from the liver (yellow arrowheads) and lungs (red arrowhead). (C) Metastatic foci of human cancer cells in the lungs immunostained with anti-HLA class I-A,B,C antibody. Original magnification, ×400.