Grade 3 or 4 % Neutropenia 9 81.8 Anemia 2 18.2 Thrombocytopenia Febrile neutropenia 2 1 18.2 9.1 Other non-hematological toxicities with grade 1 or 2 were anorexia (36.4%), constipation (36%), nausea (27.3%), diarrhea (18.2%), dysgeusia (9.1%), and stomatitis (9.1%).

Table 3: Grade3 or 4 adverse events associated with gemcitabine and S1 neoadjuvant therapy.