Figure 4: hsa-miR-337-3p targets the C6L gene at VARV genome and F2L gene at VACV gene. This figure is drawn based on positions of the genes of both VARV and VACV, so lengths of genes (kilo base pairs) are not to scale. The same colors between VARV and VACV viral genomes indicate that the genes have >90% sequence similarity to each other. VARV F and N genes combined demonstrate significant similarity with the VACV D gene where VARV A and J genes combined have shown significant similarity with the VACV A gene. Although, hsa-miR-337-3p has shown 90% identity with both the VARV and VACV viral genome, it displays perfect identity at the seed region. Both genes encode an enzyme dUTPase where they display 98% amino acid sequence identity to each other. The dUTPase is exquisitely specific for dUTP and is crucial for the fidelity of DNA replication and repair [27].