Figure 6: hsa-miR-488-3p targets M4R gene at VARV genome and L4R gene at VACV gene. This figure is drawn based on the gene’s position of both VARV and VACV, so lengths of genes (kilo base pairs) are not to scale. Identical colors between VARV and VACV viral genome indicate that genes are genetically similar. VARV F and N genes (combined) have shown significant similarity with VACV D gene where VARV A and J genes (combined) have shown significant similarity with VACV A gene. Although, hsa-miR-488-3p has shown ~90% identity with both VARV and VACV viral genome it showed perfect identity at the seed region. Both genes encoded DNA binding virion core protein where they displayed 99% amino acid sequence identity to each other. The DNA binding virion core protein is one of the major core proteins which plays a crucial role in DNA replication and/or repair.