Figure 7: hsa-miR-3128 targets the A2L gene of both VARV and VACV viral genomes. This figure is drawn based on the gene’s position of both the VARV and VACV, so lengths of genes (kilo base pairs) are not to scale. Identical colors between VARV and VACV viral genomes indicate genetic similarity. VARV F and N genes (combined) illustrate significant similarity with the VACV D gene where VARV A and J genes (combined) have shown significant similarity with the VACV A gene. Although, hsa-miR-3128 demonstrates ~90% identity with both VARV and VACV viral genomes it expressed perfect identity at the seed region. Both genes encoded a late transcription factor VLTF-3 where they presented 100% amino acid sequence identity to each other. The late transcription factor VLTF-3 is expressed during intermediate stages of infection and acts with RNA polymerase to initiate transcription from late gene promoters. VARV A2L gene encoded late transcription factor VLTF-3 exhibited 100% identity with VACV late transcription factor VLTF-3. Here, VARV late transcription factor VLTF-3 is displayed in top line and the VACV late transcription factor VLTF-3 in the lower line.