Figure 8: hsa-miR-3121 targets the H1L gene of the VARV genome and G1L gene of the VACV genome. This figure is based on the position of both VARV and VACV genomic map, and the actual relative lengths of each of the genes (kilo base pairs) are not to scale. Similar colors between VARV and VACV viral genomes indicate genetic similarity. Therefore, VARV combined F and N genes are significantly similar with the VACV D gene. Whereas for the VARV the combined A and J genes are significantly similar to the VACV A gene. Although, hsa-miR-3121 has shown ~90% identity with both VARV and VACV viral genes, they showed perfect identity at the seed region. Both genes encode an enzyme putative metalloprotease where they displayed 98% amino acid sequence identity to each other.