Result Blood culture PCR Total no. of positivesa 40/45 21/43 Total number of samples where agent detectedb 41   No. of positives, by capability, of samples tested within this subsetc 40/41 21/39 No. of positives in range of 103 cfu·ml-1 and above (as determined by blood culture)   12/12 No. of positives in range of 102 cfu·ml-1 (as determined by blood culture)   8/21 No. of positives in range of 101 cfu·ml-1 and below (as determined by blood culture)   1/10 aDefined as bacterial growth (at least one colony) observed after culture, or least one agent PCR assay returning a positive result. From number of samples tested. bNumber of samples where presence of target bacteria was identified by at least one of the capabilities, plate counts or PCR cNumber of samples testing positive using criteria defined above, of samples tested within the subset of samples where presence of agent had been indicated by at least one of the technologies.

Table 5: Summary of results from the murine model experiments.