Host bacterium Bacteriophage Family Group Sequence No. Reference(s) Y. pestis Pokrovskaya (YepE2, YpP-G) Podoviridae T7 NC_011038; JQ9657021 [14-18] Y. pestis φA1122 Podoviridae T7 NC_004777 [16,17,19-23] Y. pestis Y Podoviridae T7 JQ9657001 [16-18,24,25] Y. pestis2 R Podoviridae T7 JQ9657011 [16-18,24,26-28] Y. pestis2 d’Herelle-m (YpsP-G) Podoviridae T7 JQ9657031 [17,18,27,29,30] Y. pestis Yep-phi Podoviridae T7 HQ333270 [31] Y. pestis2 PST Myoviridae T4 UA1 [16,17,24,32,33] Y. pestis φJA1 Myoviridae T4 UA1 [16,17] Y. pestis3 PY100 Siphoviridae T1 AM076770 [34] Y. pestis L-413C Myoviridae P2 NC_004745 [15-17,22,23,35,36] B. anthracis4 β (Wβ; beta) Siphoviridae γ DQ289555 [37-40] B. anthracis4 γ (Wγ; gamma) Siphoviridae γ DQ221100 DQ222851 DQ222855 DQ289556 NC_007458 [38,39,41-47] B. anthracis Fah Siphoviridae γ NC_007814 [46-48] B. anthracis AP50 Tectiviridae ? NC_011523 [49-53] B. anthracis5 8a Myoviridae ? UA [54] B. anthracis Nk Myoviridae ? UA [55] B. anthracis DB Myoviridae ? UA [55] B. anthracis MH Podoviridae ? UA [55] B. anthracis JRB7 Inoviridae ? UA [56,57] B. anthracis K ? ? UA [43,47,58,59] B. anthracis VA-9 ? ? UA [38,47] B. abortus6 Tb (Tbilisi) Podoviridae Tb NC_019446 [60-67] B. abortus7 Np (Nepean) Podoviridae Tb UA [65] B. abortus8 Fz (Firenze) Podoviridae Tb UA9 [63,65,68-70] B. abortus10 Pr (Perote) Podoviridae Tb NC_019447 [67] B. suis11 Wb (Weybridge) Podoviridae Tb UA9 [63-65,69-71] B. suis11  S708 Podoviridae Tb UA9 [69,70,72,73] B. suis12 1330 Podoviridae? Tb? UA [74-76] B. melitensis13 Bk (Berkeley) Podoviridae Tb UA9 [63,64,70,77] B. melitensis14 311 Podoviridae? Tb? UA [75,76,78] B. abortus15 R/O Podoviridae Tb UA [64,70,79-81] B. abortus16 R/C Podoviridae Tb UA9 [65,70,79-81] B. melitensis17 Iz (Izatnagar) Podoviridae Tb UA [65,70,82] Notes: UA, unavailable. 1We (A.A. Filippov, K.V. Sergueev, and M.P. Nikolich, unpublished data) recently sequenced the genomes of PST and φJA1 (for the first time), as well as of the Pokrovskaya, Y, R, and d’Herelle-m phages. The last four genomes were virtually identical to the sequences JQ965702, JQ965700, JQ965701, and JQ965703, respectively, published by another group [18]. 2Phages R, d’Herelle-m and PST have slightly higher efficiencies of plating (EOP) on Yersinia pseudotuberculosis than on Y. pestis [17]. 3Phage PY100 lyses cultures of Y. pestis and several other species of Yersinia [34]. 4Both β and γ phages are lytic derivatives of a temperate phage W isolated from Bacillus cereus [37,41]. 58a is a spore-binding phage [54]. 6Tb lyses B. abortus at both RTD (routine test dilution, the highest phage dilution producing semiconfluent lysis) and 104 RTD, as well as lyses B. suis and B. neotomae only at 104 RTD [70]. 7Np is highly specific for B. abortus [65]. 8Fz lyses B. abortus and B. neotomae (at RTD and 104 RTD) and B. suis (only at 104 RTD) [70]. 9We (J. Farlow, A.A. Filippov, K.V. Sergueev, and M.P. Nikolich, manuscript in preparation) recently sequenced the genomes of brucellaphages Fz, Wb, S708, Bk, and R/C and observed a high level of identity with previously sequenced phages Tb and Pr [67]. 10Pr produces clear plaques on B. abortus and B. suis and turbid plaques on B. melitensis [67]. 11Wb and S708 lyse B. suis, B. abortus and B. neotomae (at RTD and 104 RTD); Wb can lyse some B. melitensis strains (also both at RTD and 104 RTD) [70]. 12Phage 1330 has a host range similar to that of Wb and S708 [74,76]. 13Bk lyses B. melitensis, B. abortus, B. suis, and B. neotomae at both titers [70,77]. 14?Phage 311 has a host range similar to that of Bk [75,76]. 15?R/O lyses B. ovis and rough strains of B. abortus at RTD and 104 RTD [70,80,81]. 16R/C lyses B. ovis, B. canis and rough strains of B. abortus at both concentrations [70,80,81]. 17Iz lyses smooth B. abortus, as well as both smooth (better) and rough (less efficiently) strains of B. neotomae, B. suis and B. melitensis [70,82].

Table 1: Bacteriophages active against biothreat bacteria.