Description of chemotherapy

Regimen	Line of chemotherapy	Objective response (RECIST)	Progression free survival (months)
Folfox1	Adjuvant (First)	PD (carcinomatosis and subcutaneous metastases)	4
Folfiri2	Second-line	PD (new hepatic metastases)	2
Paclitaxel3	Third-line	PD (+ 99 %)	2
Gemcitabine + CDDP4	Fourth-line	PR (- 42 %)	7
Vinorelbine5	Fifth-line	PD	1

Note: 1: leucovorin 400 mg/m² per 2 hours, oxaliplatin 85 mg/m² per 2 hours then 5FU 400 mg/m² bolus then 2400 mg/m² continous infusion per 46 hours, one cycle every two weeks. 2: leucovorin 400 mg/m² per 2 hours, irinotecan 180 mg/m² per 1 h 30 then 5FU 400 mg/m² bolus then 2400 mg/m² continous infusion per 46 hours, one cycle every two weeks. 3: paclitaxel 90 mg/m² per hour on days 1, 8 and 15, one cycle every four weeks. 4: cisplatin 25 mg/m² per one hour then gemcitabine 1000 mg/m² per 30 min on days 1 and 8, one cycle every three weeks. 5: oral vinorelbine at a fixed dose of 50 mg three times a week. PD: Progressive Disease; PR: Partial Response.

Table 1: Description of chemotherapy regimens used and results.