Cell line Level of   human METCAM/MUC18
expression
Tumor take,
Number of mice with tumor (%)*
Tumor size (g), mean value (±standard deviation) Number of mice with metastatic lesions to (target organs)
LNCaP (p40) none 2/6 (33%) 1.85 (±1.77) 0/6 (none)
LN-2-6 (p49) ++++ 3/9 (33%) 1.5 (±1.32) 3/9 (peri-aortic lymph nodes, ureter, kidney, seminal vesicles)
LN-2-6 (p64) + 1/5 (20%) 3 1/5 (peri-aortic lymph nodes, ureter, kidney, seminal vesicles)
LN-2-39 (p57) ++++ 3/5 (60%) 2.57 (±2.45) 3/5 (peri-aortic lymph nodes, ureter, kidney, seminal vesicles)
LN-3-5 (p58) ++++ 3/4 (75%) 1.8 (±2.7) 3/4 (peri-aortic lymph nodes, ureter, kidney, seminal vesicles)
LN-4-1 (p55) none 1/5 (20%) 0.7 0/5 (none)
LN-5-1 (p57) none 1/5 (20%) 8.6 0/5 (none)
*1 × 106 cells were injected orthotopically (to the dorsolateral lobe) of male nude mice.
Table 1: Metastasis of huMETCAM/MUC18-expressing LNCaP clones to multiple organs [25].