Characteristic No. of patients Disease-free survival Overall survival 5 years (%) P-value* 5 years (%) P-value* iNOS expression in cancer cells     0.484   0.258 0 11 72.7   90.9   1 95 66.3   64.2   2 56 58.9   64.3   iNOS expression in macrophages     0.869   0.384 0 26 61.5   53.8   1 54 61.1   63   2 56 67.9   73.2   3 26 65.4   69.2   iNOS expression in cancer cells and macrophages#     0.003   0.01 Group 1 59 55.9   54.2   Group 2 47 80.9   83   Group 3 21 76.2   76.2   Group 4 35 48.6   57.1   T status     0.001   0.066 pT1 8 87.5   87.5   pT2 25 96   84   pT3 121 59.9   62   pT4 8 37.5   50   N status     < 0.001   < 0.001 pN0 85 80   78.8   pN1 47 63.8   70.2   pN2 30 20   23.3   Distant metastasis     < 0.001   < 0.001 None detected 145 71   71   Present 17 5.9   23.5   Modified Astler-Coller stage     < 0.001   < 0.001 A 6 100   100   B 76 81.6   78.9   C 63 55.6   58.7   D 17 5.9   23.5   Sex     0.67   0.535 Male 87 62.1   67.8   Female 75 66.7   64   Differentiation     0.016   0.005 Well 23 69.6   73.9   Moderate 124 66.1   67.7   Poor 15 40   40

*Log-rank test. # Group 1 (low in cancer cells and macrophages), group 2 (low in cancer cells and high in macrophages), group 3 (high in cancer cells and low in macrophages), group 4 (high in cancer cells and macrophages).

Table 1: Disease-free and overall survival in 162 colorectal cancer patients.