| Characteristic |
Disease-free survival |
Overall survival |
| |
RR (95% C.I.) |
P value |
RR (95% C.I.) |
P value |
| iNOS expression* |
|
0.047 |
|
0.098 |
| Group 1 |
2.063 (1.036-4.107) |
0.039 |
2.145 (1.115-4.127) |
0.022 |
| Group 2 |
1 |
— |
1 |
— |
| Group 3 |
1.405 (0.480-4.109) |
0.535 |
1.551 (0.604-3.980) |
0.361 |
| Group 4 |
2.738 (1.320-5.680) |
0.007 |
2.219 (1.095-4.496) |
0.027 |
| N status |
|
< 0.001 |
|
< 0.001 |
| pN0 |
1 |
— |
1 |
— |
| pN1 |
1.461 (0.760-2.808) |
0.256 |
1.042 (0.563-1.930) |
0.895 |
| pN2 |
3.722 (1.887-7.341) |
< 0.001 |
3.642 (1.923-6.899) |
< 0.001 |
| Distant metastasis |
|
< 0.001 |
|
< 0.001 |
| None detected |
1 |
— |
1 |
— |
| Present |
6.734 (3.531-12.845) |
< 0.001 |
3.495 (1.886-6.476) |
< 0.001 |
| Differentiation |
|
0.592 |
|
0.821 |
| Well |
1 |
— |
1 |
— |
| Moderate |
1.335 (0.587-3.035) |
0.491 |
1.158 (0.562-2.388) |
0.691 |
| Poor |
1.749 (0.599-5.106) |
0.306 |
1.378 (0.507-3.743) |
0.53 |
|
| *Group 1 (low in cancer cells and macrophages), group 2 (low in cancer cells and
high in macrophages), group 3 (high in cancer cells and low in macrophages),
group 4 (high in cancer cells and macrophages. |
| Table 3: Prognostic significance of iNOS expression for colorectal cancer patients
(multivariate Cox model). |
