HPLC
TLC-spectrodensitometry
PLS
PCR
Dosage form
Compound
Found ± RSD%
Recovery % of Standard addition
Found ± RSD%
Recovery % of Standard addition
Found ± RSD%
Recovery % of Standard addition
Found ± RSD%
Recovery % of Standard addition
Mucosin Syrup B. No. 07662
Ambroxol HCl
101.77 ± 1.095
100.87 ± 0.723
100.32 ± 0.550
100.43 ± 2.075
100.45 ± 1.821
100.33 ± 0.578
100.70 ± 1.684
98.78 ± 1.072
Guaifenesin
100.45 ± 1.067
100.50 ± 0.693
101.18 ± 0.653
102.06 ± 1.681
99.82 ± 1.880
100.47 ± 0.850
99.96 ± 1.986
101.70 ± 0.173
Mucosin Capsules B. No. 10301
Ambroxol HCl
99.01 ± 0.856
100.05 ± 1.298
99.45 ± 1.941
99.57 ± 2.006
99.47± 0.82
100.06 ± 0.418
100.13 ± 0.92
100.50 ± 0.500
Ambroxol tablets B. No. 080078A
Ambroxol HCl
99.71 ± 1.118
99.80 ± 1.997
99.34 ± 1.151
99.28 ± 1.731
100.13 ± 1.75
99.94 ± 0.587
100.80 ± 1.76
100.00 ± 1.00
Ambroxol drops B. No. 091111A
Ambroxol HCl
101.30 ± 0.440
100.37 ± 1.354
99.87 ± 0.987
99.28 ± 1.303
101.37 ± 1.52
99.89 ± 1.018
102.03 ± 1.44
100.11 ± 1.018
Table 4:
Quantitative determination of Ambroxol HCl and Guaifenesin in pharmaceutical dosage forms by the proposed methods and application of standard addition technique