HPLC TLC-spectrodensitometry PLS PCR Dosage form Compound Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition Mucosin Syrup B. No. 07662 Ambroxol HCl 101.77 ± 1.095 100.87 ± 0.723 100.32 ± 0.550 100.43 ± 2.075 100.45 ± 1.821 100.33 ± 0.578 100.70 ± 1.684 98.78 ± 1.072 Guaifenesin 100.45 ± 1.067 100.50 ± 0.693 101.18 ± 0.653 102.06 ± 1.681 99.82 ± 1.880 100.47 ± 0.850 99.96 ± 1.986 101.70 ± 0.173 Mucosin Capsules B. No. 10301 Ambroxol HCl 99.01 ± 0.856 100.05 ± 1.298 99.45 ± 1.941 99.57 ± 2.006 99.47± 0.82 100.06 ± 0.418 100.13 ± 0.92 100.50 ± 0.500 Ambroxol tablets B. No. 080078A Ambroxol HCl 99.71 ± 1.118 99.80 ± 1.997 99.34 ± 1.151 99.28 ± 1.731 100.13 ± 1.75 99.94 ± 0.587 100.80 ± 1.76 100.00 ± 1.00 Ambroxol drops B. No. 091111A Ambroxol HCl 101.30 ± 0.440 100.37 ± 1.354 99.87 ± 0.987 99.28 ± 1.303 101.37 ± 1.52 99.89 ± 1.018 102.03 ± 1.44 100.11 ± 1.018

Table 4: Quantitative determination of Ambroxol HCl and Guaifenesin in pharmaceutical dosage forms by the proposed methods and application of standard addition technique